Ellen Pompeo Gets Real About Struggles With Co-Stars On Grey’s Anatomy

Actors often spend years inhabiting a single role and for Ellen Pompeo, her time as Meredith Grey on Grey’s Anatomy was nothing short of life‑defining. After stepping down as a series regular in 2023, Pompeo took to the Call Her Daddy podcast this week to share a candid look back at what it was really like behind the scenes of one of TV’s longest-running dramas.

In the episode, Pompeo reflected on the show’s most significant moments, her awkward pay conversations, and some surprising revelations about her relationships with co-stars. She didn’t hold back, admitting she cried filming a love scene with T.R. Knight (who played George O’Malley) and clarifying that she didn’t harbor resentment toward Patrick Dempsey over their salary gap.

Host Alex Cooper asked Pompeo how she dealt with conflict among such a large cast. Her answer was refreshingly straightforward. “There’s no playbook for it,” she said. “People aren’t going to like you, and that’s just life. I tell my daughter Stella all the time: you won’t like everyone, and not everyone’s going to like you back. It sucks sometimes, but you have to accept it.”

Pompeo went on to explain how her position of influence on set occasionally put her in the awkward role of advocate. She’d step up for cast or crew members who felt overlooked — only to be told, “I don’t need you to fight my battles.” “That was a punch in the gut,” she admitted. “I thought I was helping, and I ended up feeling like I’d overstepped.”

She acknowledged that working on set could sometimes be challenging.

She stressed that every situation required its approach. “I’ve messed up plenty,” Pompeo confessed. “I’ve put my foot in my mouth more times than I can count — on and off the show. All you can do is learn and move on.” Her honesty underscored a central theme of her reflection: intentions matter, but so does self‑awareness.

Pompeo also shared what it’s like being perceived as “tough.” She laughed, recalling how her no-nonsense exterior and salty language sometimes led people to misjudge her.“I’ll swear like a sailor, and I won’t hesitate to honk back at someone cutting me off in traffic,” she said with a chuckle.

Yet beneath that tough shell, she described herself as “super soft and chewy inside.” It’s a complexity she’s come to embrace after nearly two decades in a role that demanded emotional vulnerability.

Pompeo portrayed Meredith Grey.

The conversation touched on the gender pay gap without turning into a headline-grabbing feud. When Cooper asked if she was upset about earning more than Dempsey, Pompeo said flatly, “No. We had different contracts and different negotiations. It is what it is.” Her pragmatic approach stood in contrast to many public salary disputes, demonstrating a willingness to discuss tough topics without drama.

Looking back on her tenure with Grey’s Anatomy, Pompeo’s reflections were grounded in growth rather than grievance. She acknowledged the challenges of navigating fame, power dynamics, and interpersonal clashes, but she also highlighted the lessons those experiences taught her about leadership, empathy, and authenticity.

As the interview wrapped up, Pompeo circled back to the idea of acceptance - of herself and others. “You can’t control how people see you,” she said. “All you can do is show up as your honest self, own your mistakes, and keep moving forward.”

For fans of Grey’s Anatomy and anyone who’s ever worked in a high-pressure environment, her words offer a clear-eyed reminder that success isn’t just about talent - but about resilience, humility, and staying true to who you are.